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Bupropion, cimetidine, diphenhydramine, fluoxetine, hydroxychloroquine, paroxetine, propafenone, quinidine, ritonavir, terbinafine, thioridazine may increase plasma metoprolol concentrations, resulting in decreased cardioselectivity of the drug. Pending further experience with combination therapy with paroxetine and metoprolol, caution should be exercised metoprolol succinate er coupon paroxetine and metoprolol are used concomitantly.1% to 0.

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