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|Trade names||Prometrium, Utrogestan, Endometrin, Crinone, others|
|Pregnancy category||B (US)|
|Routes of administration||• By mouth (capsule) • Sublingual (tablet) • Topical (cream, gel) • Vaginal (capsule, tablet, gel, suppository, ring) • Rectal (suppository) • IM injection (oil solution) • SC injection (aq. soln.) • Intrauterine (IUD)|
|Drug class||Progestogen; Antimineralocorticoid; Neurosteroid|
|ATC code||G03DA04 ( WHO )|
|Legal status||In general: ℞ (Prescription only)|
|Bioavailability||Oral: <2.4%  Vaginal: 4–8%   |
|Protein binding||98–99%:   • Albumin: 80% • CBG: 18% • SHBG: <1% • Free: 1–2%|
|Metabolism||Mainly liver: • 5α- and 5β-reductase • 3α- and 3β-HSD • 20α- and 20β-HSD • Conjugation • 17α-Hydroxylase • 21-Hydroxylase • CYPs (e.g., CYP3A4)|
|Metabolites||• Dihydroprogesterones • Pregnanolones • Pregnanediols • 20α-Hydroxyprogesterone • 17α-Hydroxyprogesterone • Pregnanetriols • 11-Deoxycorticosterone (And glucuronide/sulfate conjugates)|
|Elimination half-life||• Oral: 5 hours (with food)  * Sublingual: 6–7 hours  • Vaginal: 14–50 hours   • Topical: 30–40 hours  • IM: 20–28 hours    • SC: 13–18 hours  • IV: 3–90 minutes |
|Excretion||Bile and urine  |
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|Prometrium product names||agolutin, belgest, ciclosterona, crinone, cyclogest, cygest, darstin, endometrin, esolut, estima, evapause, florgynal, geslutin, gestagen, gester, gesterol, gestone, hormoral, lugesteron, luteina, luteum, lutogynestryl, lutogynon, mafel, mastoprofen, menaelle, microgest, naturogest, premastan, prochieve, progeffik, progehormon, progenar-gele, progendo, progest, progestan, progesteron, progesterona, progesteronum, progestin, progestogel, progeston, progestosol, prolusteron, proluton, prontogest, prosphere, susten, trophigil, utrogest, utrogestan, utrogestran, vasclor|
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