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Fold changes in A TNF-; B IL-1; C IL-6 pro-inflammatory cytokines D IL-4; E IL-10 anti-inflammatory cytokines in plasma.
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Originally synthesized in France in the 1970s, modafinil was approved as a treatment for narcolepsy and other sleep disorders in 1998.Modafinil has reinforcing properties, as evidenced by its self-administration in monkeys previously trained to self-administer cocaine; Modafinil was also partially discriminated as stimulant-like. The optical enantiomers of Artvigil vs modalert reddit have similar pharmacological actions in animals.
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