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44 Renal elimination is the major route of excretion with about 60% of an administered carvedilol davis drug guide recovered in urine, largely as inactive pyridine metabolites.Dosage of the fixed-combination preparation should be adjusted according to the patient's response at intervals of 7-14 days.

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Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers.

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